I hope, one of these days, when the Human Genome Project has finished the important work of isolating the genes that cause breast cancer and heart disease and birth defects and whatnot, and perhaps treated …

Dear Sars,
I met a man while playing a game on Yahoo, and struck up an email exchange based on several likes and dislikes we discovered about each other while playing the game. At first it …

Please help me figure out what to do about our cat. Here’s the background: She’s about five years old. We got her when she was one. She’s very sweet and friendly, and at first she …

I’ve been so impressed with your Vine advice that I’ve sometimes wished I had a problem just so I could see what you would tell me to do. Now I have that problem. Wishes suck.
I …

Dear Sars,
I agree with your take on MP’s problem. I would add that sometimes people inexperienced with drug and alcohol use can overestimate the seriousness of it when they see it. Mary’s drug and alcohol …

“Well, that’s a very sad story, and I feel for you, but it isn’t time for your lunch.”
“Get down. Get down. No, no, no — down on the floor. The desk is for humans. The …

Sars, another answer for Quoi Faire would be to check into refinancing the mortgage now that she has that full-time good job. Having the job is a substantial financial change for the positive, so a …

Hey there Sars! I’ve been reading your site for a while now and find you very astute, and very funny. I’m hoping that you can help me with another usage question…
A while ago, a friend …

Hey Sars! I love TN, especially the Collected Cat Rants, and when I realized I had a dilemma, I thought it should go to you.
Welcome to The High School Soap Opera. The key players are …

Sars,
I’m a 22-year-old virgin who has absolutely no desire to have sex. I’ve had two boyfriends in my life, one when I was 17 and one when I was 20, but again, no desire to …